Ahn. Lab at Yonsei Chemistry
Materials for Electrochemical Energy Conversion
02-2123-2634
Signal Analysis
Cell-to-cell Signal Analysis
Understanding cellular metabolism is crucial for understanding cell function, and respiration plays a key role in this process. Cellular respiration varies depending on the type and state of the cell. Such heterogeneity among cells is difficult to discern using methods that measure thousands or millions of cells simultaneously. Moreover, intercellular signaling is known to play an essential role in processes such as stem cell differentiation and cancer cell response to chemotherapy. To gain a clear understanding of these phenomena, measurements at the single-cell level are necessary.
Reactive oxygen species (ROS) and reactive nitrogen species (RNS), which are key metabolic molecules involved in cellular respiration and intercellular signaling, play significant roles in gene expression, apoptosis, and the mechanisms of various diseases. Our laboratory conducts research utilizing scanning electrochemical microscopy (SECM) to precisely measure ROS and RNS at the single-cell level. SECM is a non-invasive, high-resolution electrochemical imaging tool capable of observing chemical changes in the intracellular and extracellular microenvironment in real time, providing powerful insights into cellular processes. Using a platinized carbon nanoelectrode fabricated through laser puller and Pt black deposition, we can measure the generation of reactive species within cells without causing any damage to the cells.
Volatile Organic Compound Sensing for Proactive Disease Detection
Electrochemical sensors have the advantages of high selectivity, portability, and low energy consumption. We aim to develop a system that utilizes electrochemical sensors to detect compounds among the VOCs exhaled by humans, which can serve as biomarkers for diseases. This system will enable the proactive and non-invasive diagnosis of various diseases.